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Design changes in the second generation device using improved electronic components, circuit boards and digital signaling technology, resulted in reduced weight and increased operational efficiency for people with glioblastoma multiforme, improving the patient experience with TTFields treatment. (Top left, 1st generation Optune; Top Right, 2nd generation Optune; Bottom panels, patients wearing 2nd generation Optune with white and tan arrays).
Agentes imunossupressores saiba como as ciclofosfamidas identicamente conjuntamente podem possibilitar ser indicados pelo procedimento da neuropatia do Genero crônico que pode ser resistente a outros tratamentos.
NovoCure has not confirmed its next earnings publication date, but the company's estimated earnings date is Thursday, July 25th, 2024 based off last year's report dates. Learn more on NVCR's earnings history.
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TTFields’ unique mechanism of action underscores key points related to its effective administration and clinical benefit. Unlike chemotherapeutic agents, TTFields are only active while the arrays are affixed to the scalp and the alternating electric fields are generated between the transducer arrays. As a loco-regional and non-invasive targeted therapy, TTFields has the benefit of avoiding systemic adverse events associated with chemotherapy and targeted systemic therapies. The primary treatment-associated adverse event experienced by some patients with TTFields is skin irritation below the arrays, which is predictable and easily manageable in the majority of cases.
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Simulations and modelling are the primary tools for obtaining these essential data (Fig. 4). Simulation-based studies using realistic head models have shown that TTFields effectively penetrate the brain and tumour tissue. The field distribution is heterogeneous and depends on the anatomy of the individual patient, the physical properties of the various tissue types and the location of the tumour10. The position of arrays can therefore be optimized using the NovoTAL System to deliver maximal field intensities to the tumour region of the individual patient10,11.
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Stupp et al. in 20051 reported what is still to this day considered the definitive protocol for the treatment of newly diagnosed GBM – sometimes referred nervocure to as the Stupp protocol. Following maximal safe surgical tumour removal, the patient received RT plus TMZ followed by TMZ maintenance therapy.